Darier’s disease, also known as keratosis follicularis, is a rare genetic skin disorder characterized by persistent, waxy, and scaly skin lesions. The condition affects approximately 1 in 30,000 to 100,000 individuals worldwide, with varying degrees of severity. While Darier’s disease is a distinct skin condition, it has been known to intersect with other skin disorders, complicating both diagnosis and treatment. This article will delve into the relationship between Darier’s disease and other skin conditions, exploring the challenges and opportunities for improving patient outcomes.